Cytoplasmic neat1 suppresses aml
WebApr 17, 2024 · Cytoplasmic NEAT1_1 has also been described as a regulator of stem cell self-renewal in acute myeloid leukaemia (AML) [ 48 ]. In contrast to its role in breast cancer, however, NEAT1_1 functions as a tumour suppressor in non-transformed blood cells. http://english.ibp.cas.cn/resources_23473/latest_important_articles/index_13.html
Cytoplasmic neat1 suppresses aml
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WebApr 7, 2024 · Background Acute myeloid leukemia (AML) is a heterogeneous hematological disease. Our purpose of the research was to investigate the regulatory influence of long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1)/microRNA-338-3p (miR-338-3p)/CREB3 regulatory factor (CREBRF) in AML progression. Methods The … WebCytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling Huiwen Yan, Zhi Wang, Yao Sun, Liangding Hu, Pengcheng Bu . 2 Supplemental Figure 1. NEAT1 is upregulated in differentiated AML cells.
WebNov 17, 2024 · Collectively, the findings show NEAT1_1 is translocated from the nucleus to the cytoplasm and acts as a tumor suppressor in AML. NEAT1 is downregulated in acute … WebMar 15, 2024 · The four major types of leukemia are acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML) and chronic lymphocytic leukemia (CLL). The acute form of leukemia usually affects younger individuals and is more severe due to its sudden onset and rapid proliferation.
WebOct 5, 2024 · Herein, an adverse effect of NEAT1 is reported, showing that the short isoform, NEAT1_1 suppresses acute myeloid leukemia (AML) development. NEAT1_1 … WebOct 13, 2024 · It is demonstrated that NEAT1_1 suppresses leukemogenesis and LSC function but is dispensable for normal hematopoiesis. Mechanistically, NEAT1_1 is …
WebHerein, an adverse effect of NEAT1 is reported, showing that the short isoform, NEAT1_1 suppresses acute myeloid leukemia (AML) development. NEAT1_1 is downregulated in …
popup anheftenWebJul 20, 2024 · BackgroundChronic myeloid leukemia (CML) is an acquired hematopoietic stem malignant disease originating from the myeloid system. Long non-coding RNAs (lncRNAs) have been widely explored in cancer tumorigenesis. However, their roles in CML remain largely unclear.MethodsThe peripheral blood mononuclear cells (PBMCs) and … popup animation wpfWebDec 2, 2024 · NEAT1 lncRNA is a major component of paraspeckles that has been linked to several malignancies. In this study, analysis of the Cancer Genome Atlas (TCGA) database and validation in HCV-induced HCC tissue and serum samples showed significantly high expression of NEAT1 in patients with liver cancer. ... Cytoplasmic NEAT1 suppresses … sharon hulin psychologistWebCytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling, Adv Sci, 5 Oct 2024 [2024-10-05] A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1, J Am Chem Soc , 1 Oct 2024 pop up angel christmas cardshttp://english.ibp.cas.cn/resources_23473/latest_important_articles/202410/t20241013_284702.html sharon humphrey facebookWebJan 26, 2024 · NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling As an essential component of paraspeckles, nuclear paraspeckle assembly transcript 1 (NEAT1) localizes in the nucleus, promoting progression of various malignant solid tumors. sharon humphries facebookWebMay 5, 2024 · Cytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling 2024, Advanced Science Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation 2024, Phytotherapy Research sharon humphries